{..CIPROLOXACIN HCL..}
(Film coated tablets)
COMPOSITION:
Cyrocin 250 MG Tablet is film coated tablet contents ciprofloxacin hydrochloride U.S.P…... 250 mg.
Cyrocin 500 MG Tablet is film coated tablet contents ciprofloxicin as hydrochloride U.S.P….. 500mg
Description:
Cyrocin is fluorinated 4- quinolone or antibacterial with a wider spectrum of activity then nalidixic acid and more favourable pharmacokinetics allowed it is used is systematic infection.
Mechanism Of Action:
Ciprofloxacin is a member of the fluoroquinolone class of antibacterial agent ciprofloxacin is a broad spectrum antibiotic that is active against both germ-positive and Gram-Negative bacteria the bacterial action of ciprofloxacin result from inhabitation of the enzymes topofisomerase ll and topoisomerase lV.which are required for bacterial DNA replication, transcription, repair and recombination.
Pharmacokinetics:
Ciprofloxacin is ready and well observed from the gastrointestinal tract oral.bioavailability is about 70 to 80% and peak plasma concentration of about 2.4 micrograms per Mol. occure 1 to 2 hour after 500 mg oral dose absorption of the ciprofloxacin may be delayed by the presence of food, but is not substantially affected overall.
The binding of ciprofloxacin to serum protein is 20% to 40% which is not likely to be high enough to cause significant protein binding interaction with Other Drugs.
Indications And Usage:
Cyrocin tablet is indicated for the treatment of infection caused by susceptible isolates of the designated micro-organisms in the condition and patient population listed below.
Urinary tract infection:
Cyrocin tablet is indicated in adult patients for treatment of urinary tract infection caused by Escherichia coli.
Acute uncomplicated cystitis:
Cyrocin tablet is indicated in Adult female patient for treatment of acute uncomplicated cystitis caused by Escherichia coli.
Chronic bacterial Prostatitis:
Cyrocin tablet is indicated in adverb patient for treatment of chronic bacterial Prostatitis caused by Escherichia coli.
Lower respiratory tract infections:
Cyrocin tablet is indicated in equal patient for treatment of lower respiratory tract infection caused by Escherichia coli cyrocin tablet is also indicated for the treatment of acute exacerbation of chronic brochititis cause by Moraxella catarrhails.
Acute sinusitis:
Cyrocin tablet is indicated in head rotation for treatment of acute Sinusitis caused by a haemophilus influenzae, streptococcus pneumoiaw.
Skin and skin structure infection:
Cyrocin tablet is indicated in adult patient for treatment of skin and skin structure infection caused by citrobactor freundii, methicillin susceptible.
Dosage and administration dosage in adults:
Determination of dosage and duration for any particular patient must take into consideration the severity and nature of the infection the susceptibility of the causative microorganism the integrity of the patient host defence mechanism and the status of renal and apathetic function.
Urine specific for population: pregnancy:
Pregnancy category C because no adequate or well control study has been conduct in pragnant women.cefrofloxacin should be used during pregnancy only if the patient benefit justify the potential risk to the fetus.
Nursing mother:
ciprofloxacin is excreted in the breast milk because of the potential risk of serious adverse reaction in the infants nursing from Mother taking cyrocin a decision should be made whether to discontinue nursing or to discontinue the drug taking into account the important of the drug to the moth
Paediatric uses:
Ciprofloxacin is not a drug of first choice in the pediatric population due to an increased incidence of adverse reaction compared to the control including event related to joint and / or surrounding tissues.
warnings and precautions
The following precaution and warning should be measured during cyrocin treatment are
Fluoroqinolone Including ciprofloxacin have neuromuscular blocking activity and m.ay exacerbate muscle weakness in person with myasthenia gravis.ciprofloxacin in patient with
known history of myasthenia gravis.
Manufactured by:
Titlis Pharma
for
Highnoon Laboratories Ltd
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