Tenormin: Uses, Dosage & Side Effects - Drugs.com

                                                                  {.. Tenormin..}

                                                                     (Atenolol)

Composition:
Each film coated tablet content 25 mg,50 mg,100 mg of atenolol.
 Injection for intravenous use presented as an isotonic citrate buffered,aqueous solution containing 5 mg of atenolol ph.Eur.in 10 ml.

Therapeutic Indications:
 Hypertension
Angina pectoris
cardiac arrhythmias

Posology And Method Of Administration:
The dose must always be adjusted  to individual requirement of the patient with the lowest possible starting dosage.
 the following are guidelines.

                                                              Adult:

Hypertension:
One tablet daily most patient respond 200 mg daily given orally as a single dose some patient however will respond to 50 mg given as a single daily dose the effect will be fully established after 1 or 2 week a further reduction in blood pressure may be achieved by combining tenormin with other antihypertensive agents for example co administration of tenorman with a diuretic provides a Highly Effective and convenient antihypertensive therapy.

Angina:
Most patient with angina pectoris will respond 200 mg given orally once or 50 mg given twice daily it is unlikely that additional benefit will be gained by increasing the dose.

Cardiac Arrhythmia’s:
A suitable initial dose of tenormin is 2.5 mg injected intravenously over 2.5 minute period this may be repeated at 5 minute interval until a response is observed up to a maximum dosage of 10 mg tenormin is given by infusion 0.15 MG per KG body weight may be administered over a 20 minute period if required the Injection or infusion may be repeated every 12 hour.Having controlled the arrhythmias with intravenous tenormin a suitable oral maintenance dose ages 50 to 100 MG daily given as a single dose.

Elderly:
 Does requirement may be reduced especially in patient with impaired renal function.

Children:
There is no paediatric experience with tenormin and for this reason it is not recommended for use in children.

Renal Failure:
 since the tenormin excreted via then kidney the door that should be reduced in case of severe impairment of renal function no significant accumulation of tenement occur in patients who have a creatinine clearance greater than 35 ml per minute per 1.73 metre square.

Contraindications:
Tenorman as with other Beta blocker should not be used in patient with any of the following:
 Hypersensitivity to the active substance, or any of the excipient bradycardia cardiogenic shock. hypertension metabolic acidosis;Severe peripheral articles circulatory disturbance second or third degree heart block sick sinus syndrome;Untreated  phaeochromocytoma;
Uncontrolled heart failure.

                                  Special warnings and precaution for use

tenormin as with other Beta blocker:
should not be with drawn abruptly. should be withdrawn gradually over a period of 7-14 days to facilitate.
A reduction in the beta blocker dosage.Patient should be followed during withdrawal especially those with ischaemic heart diseases.

Pregnancy and lactation:
The tenormin cross the placental barrier and appeared in the cord blood no studies have been performed on the use of tenormin in the first trimester and the possibility of foetal injury cannot be excluded.Tenormin has been used under close supervision for the treatment of hypertension in the third trimester. Administration of the tenormin to pregnant women in the management of mild to moderate hypertension has been associated with intra uterine growth retardation:

Effect on ability to drive and used machines:
Used as  unlikely to result in any impairment of the ability of patient to drive or operate machinery however it should be taken into account that occasionally dizziness or fatigue may occur.

Undesirable effect:
Tenormin is well tolerated.In clinical studies the undesired events trip reported are usually attributable to the pharmacological action of atenolol.
Following undesired events listed by body system has been reported with the following frequencies very common >10% common 1-9.9% uncommon 0.1-0.9%.

Overdose:
The symptoms of overdosage May include bradycardia hypotension acute cardiac insufficiency and bronchaspasm.


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