Sofvasc
Tablets
Each tablet contain:
Amlodipine besylate eq. to amlidopine BP/Eur. P …...5 & 10 mg
Description:
Amlodipine is a Calcium Ion influx inhibitor and the transmembrane influx of calcium ion into cardiac and smooth muscles.the antihypertensive action is due to direct relaxant and effect on vascular smooth muscle the exact mechanism of action with regard to angina has not been fully determined but amlidopine reduce total ischemic burden by the following to actions.
1= Amlidopine dilates peripheral thus reduce the total peripheral resistance against with the heart work.since there is no associated reflex tachycardia this unloading of the heart reduce myocardial energy consumption and oxygen requirement and probably account for the effectiveness of amlidopine in myocardial ischemia.
2= The mechanism of action of amlodipine probably involved dilation of the main coronary arteries and coronary arterioles but a normal and ischemic region. this dilqtion increase myocardial oxygen delivery in patient with coronary artery spasm.
Pharmacology:
After oral administration of therapeutic dose.amlidopine is not defined as well obsorbed.The terminal plasma elimination Half-Life is about 35-65 hour and consistent with once daily dosing. steady state plasma level are achieved after 7-8 days of constructive dosing and define is extensively metabolized by the liver to inactive metabolies with 10% of parent compound and 60% of metabolies excreted in urine. In patient with hypertension once daily dosing provids clinically significant reduction of blood pressure in both supine and standing position throughout the 24 hour interval.
Indicationns
hypertension:Sofvasc tablet are indicated for the first line treatment of hypertension and can control blood pressure as a sole agent in majority of patients all through the thiazide diuretic, Beta blocker of an inhibitor may be given in addition if required.
Myocardial ischemia:
Sofvasc tablet are indicated for the first line treatment of myocardial ischemia either alone or in combination with Other anti-anginal Drugs.
Contra-indication:
Amlodipine is contraindicated in patient with known hypersensitivity to dihydropyridiness.
Possible adverb effect:
Amlidopine is generally well tolerated while most commonly observed side effect were headache, edema, fatigue, nausea flushing and dizziness.
Drug interactions:
Amlidopine has been safely administrated with thaizide diuretic Beta blocker angiotensin converting enzyme inhibitors long active nitrate sublingual nitroglycerine non steroidal anti inflammatory drug.inhibtors and oral hypoglycemic drugs.
Warnings:
Use in pregnancy and lactation: Safety of the drug has not been established in pregnancy and lactation:
Used in elderly:
Normal dosage the mines are recommended in into the patient. Use in renal faliur:
Amlodipine is extensively metabolised to inactive metabolities with 100% excreted as unchanged in the urine. therefore and define may be used in such patient at normal dose.
Used in hepatic impairment
impairment:
Half life of drug is prolonged in patient with hepatic impairment and dosage recommendation in such patient have not been established the drugs should therefore be administered with caution in such patients.
Storage/precautions:
store in a cool dry and dark place between 15-30 degree centigrade keep all medicine out of the children's reach.
Presentation:
Sofvasc 5 and 10 mg tablet are available in packing containing 30 tablet Wilsonspecs.
complete medical information available only for doctor on request.
Manufactured by
Wilson Pharmacuticles
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