Monday 11 December 2017
Tuesday 7 November 2017
Monday 6 November 2017
Monday 7 August 2017
SOFVASC TABLETS Amlodipine (Besylate):5mg
Sofvasc
Tablets
Each tablet contain:
Amlodipine besylate eq. to amlidopine BP/Eur. P …...5 & 10 mg
Description:
Amlodipine is a Calcium Ion influx inhibitor and the transmembrane influx of calcium ion into cardiac and smooth muscles.the antihypertensive action is due to direct relaxant and effect on vascular smooth muscle the exact mechanism of action with regard to angina has not been fully determined but amlidopine reduce total ischemic burden by the following to actions.
1= Amlidopine dilates peripheral thus reduce the total peripheral resistance against with the heart work.since there is no associated reflex tachycardia this unloading of the heart reduce myocardial energy consumption and oxygen requirement and probably account for the effectiveness of amlidopine in myocardial ischemia.
2= The mechanism of action of amlodipine probably involved dilation of the main coronary arteries and coronary arterioles but a normal and ischemic region. this dilqtion increase myocardial oxygen delivery in patient with coronary artery spasm.
Pharmacology:
After oral administration of therapeutic dose.amlidopine is not defined as well obsorbed.The terminal plasma elimination Half-Life is about 35-65 hour and consistent with once daily dosing. steady state plasma level are achieved after 7-8 days of constructive dosing and define is extensively metabolized by the liver to inactive metabolies with 10% of parent compound and 60% of metabolies excreted in urine. In patient with hypertension once daily dosing provids clinically significant reduction of blood pressure in both supine and standing position throughout the 24 hour interval.
Indicationns
hypertension:Sofvasc tablet are indicated for the first line treatment of hypertension and can control blood pressure as a sole agent in majority of patients all through the thiazide diuretic, Beta blocker of an inhibitor may be given in addition if required.
Myocardial ischemia:
Sofvasc tablet are indicated for the first line treatment of myocardial ischemia either alone or in combination with Other anti-anginal Drugs.
Contra-indication:
Amlodipine is contraindicated in patient with known hypersensitivity to dihydropyridiness.
Possible adverb effect:
Amlidopine is generally well tolerated while most commonly observed side effect were headache, edema, fatigue, nausea flushing and dizziness.
Drug interactions:
Amlidopine has been safely administrated with thaizide diuretic Beta blocker angiotensin converting enzyme inhibitors long active nitrate sublingual nitroglycerine non steroidal anti inflammatory drug.inhibtors and oral hypoglycemic drugs.
Warnings:
Use in pregnancy and lactation: Safety of the drug has not been established in pregnancy and lactation:
Used in elderly:
Normal dosage the mines are recommended in into the patient. Use in renal faliur:
Amlodipine is extensively metabolised to inactive metabolities with 100% excreted as unchanged in the urine. therefore and define may be used in such patient at normal dose.
Used in hepatic impairment
impairment:
Half life of drug is prolonged in patient with hepatic impairment and dosage recommendation in such patient have not been established the drugs should therefore be administered with caution in such patients.
Storage/precautions:
store in a cool dry and dark place between 15-30 degree centigrade keep all medicine out of the children's reach.
Presentation:
Sofvasc 5 and 10 mg tablet are available in packing containing 30 tablet Wilsonspecs.
complete medical information available only for doctor on request.
Manufactured by
Wilson Pharmacuticles
Thursday 3 August 2017
Tenormin: Uses, Dosage & Side Effects - Drugs.com
{.. Tenormin..}
(Atenolol)
Composition:
Each film coated tablet content 25 mg,50 mg,100 mg of atenolol.
Injection for intravenous use presented as an isotonic citrate buffered,aqueous solution containing 5 mg of atenolol ph.Eur.in 10 ml.
Therapeutic Indications:
Hypertension
Angina pectoris
cardiac arrhythmias
Posology And Method Of Administration:
The dose must always be adjusted to individual requirement of the patient with the lowest possible starting dosage.
the following are guidelines.
Adult:
Hypertension:One tablet daily most patient respond 200 mg daily given orally as a single dose some patient however will respond to 50 mg given as a single daily dose the effect will be fully established after 1 or 2 week a further reduction in blood pressure may be achieved by combining tenormin with other antihypertensive agents for example co administration of tenorman with a diuretic provides a Highly Effective and convenient antihypertensive therapy.
Angina:
Most patient with angina pectoris will respond 200 mg given orally once or 50 mg given twice daily it is unlikely that additional benefit will be gained by increasing the dose.
Cardiac Arrhythmia’s:
A suitable initial dose of tenormin is 2.5 mg injected intravenously over 2.5 minute period this may be repeated at 5 minute interval until a response is observed up to a maximum dosage of 10 mg tenormin is given by infusion 0.15 MG per KG body weight may be administered over a 20 minute period if required the Injection or infusion may be repeated every 12 hour.Having controlled the arrhythmias with intravenous tenormin a suitable oral maintenance dose ages 50 to 100 MG daily given as a single dose.
Elderly:
Does requirement may be reduced especially in patient with impaired renal function.
Children:
There is no paediatric experience with tenormin and for this reason it is not recommended for use in children.
Renal Failure:
since the tenormin excreted via then kidney the door that should be reduced in case of severe impairment of renal function no significant accumulation of tenement occur in patients who have a creatinine clearance greater than 35 ml per minute per 1.73 metre square.
Contraindications:
Tenorman as with other Beta blocker should not be used in patient with any of the following:
Hypersensitivity to the active substance, or any of the excipient bradycardia cardiogenic shock. hypertension metabolic acidosis;Severe peripheral articles circulatory disturbance second or third degree heart block sick sinus syndrome;Untreated phaeochromocytoma;
Uncontrolled heart failure.
Special warnings and precaution for use
tenormin as with other Beta blocker:
should not be with drawn abruptly. should be withdrawn gradually over a period of 7-14 days to facilitate.
A reduction in the beta blocker dosage.Patient should be followed during withdrawal especially those with ischaemic heart diseases.
Pregnancy and lactation:
The tenormin cross the placental barrier and appeared in the cord blood no studies have been performed on the use of tenormin in the first trimester and the possibility of foetal injury cannot be excluded.Tenormin has been used under close supervision for the treatment of hypertension in the third trimester. Administration of the tenormin to pregnant women in the management of mild to moderate hypertension has been associated with intra uterine growth retardation:
Effect on ability to drive and used machines:
Used as unlikely to result in any impairment of the ability of patient to drive or operate machinery however it should be taken into account that occasionally dizziness or fatigue may occur.
Undesirable effect:
Tenormin is well tolerated.In clinical studies the undesired events trip reported are usually attributable to the pharmacological action of atenolol.
Following undesired events listed by body system has been reported with the following frequencies very common >10% common 1-9.9% uncommon 0.1-0.9%.
Overdose:
The symptoms of overdosage May include bradycardia hypotension acute cardiac insufficiency and bronchaspasm.
Manufactured By:
searle private limited
Tuesday 1 August 2017
Glucophage Oral : Uses, Side Effects, Interactions, Pictures, Warnings
{..GLUCOPHAGE..}
(METFORMIN HYDROCLORIDE)
TABLETS
(MERCK SERONO)
Composition:
Glucophage tablet 250 mg:
Each film coated tablet contain metformin hydrochloride ph. Eur……….250 mg
Glucophage tablet 500 mg:
Each film coated tablet contain metformin hydrochloride ph. Eur……….500 mg
Glucophage tablet 850 mg:
Each film coated tablet contain metformin hydrochloride ph. Eur……….850 mg
Glucophage tablet 1000 mg:
Each film coated tablet contain metformin hydrochloride ph. Eur……….100 mg
Read all of this leaflet carefully before you start taking this medicine because it contain important information for you:
keep this leaflet,you may need to read it again.if you have further questions, ask your doctor or your Pharmacist.
This medicine has been prescribed for you only.
Do not pass it into other It may harm them even if their sign of illness are the same as your.
If you get any side effect talk to your doctor or pharmacist.
This includes any possible Side Effects not listed in this leave it what is in this leaflet.
what is glucophage tablet?
what are the indication for glucophage tablet ?
what should be the dose of glucophage Tablet?
what are the contraindication of glucophage best tablet?
what are the adverse effect of glucophage tablet?
what is glucophage tablet?
Glucophage is a medicine to treat diabetes.it belongs to a group of medicine called biguanides. insulin is a hormone produced by the pancreas that makes your body take in glucose from the blood your body uses glucose to produce energy stores.
It for future use
If you have diabete your pancreas does not make in insulin or your body is not able to use properly the insulin it produce this lead to a high level of glucose in your blood glucose help to lower your blood glucose to as normal as level as possible.If you are an overweight, adult,taking glucophage over a long period of time also help to lower the risk of complications associated with daibetes.
What are the indication for glucophage tablet:
Glucophage is used to treat patient with type 2 diabetes with diet and exercise alone have not been enough to control your blood glucose levels.
It is used particularly in overweight patient adult can take Glucophage on its own or together with other medicine to treat diabetes children 10 years and over and adolescent can take glucophage
on its on or together with incident it is also indicated for the prevention of type 2 Diabetes mellitus in patients with pre-diabetes and at least one additional risk factor in whom Lifestyle modification alone have not reach adequate glycaemic control.
What should be the dose of glucophage tablet?
Always take Glucophage exactly as your doctor has told you check with your doctor or pharmacist. if you are not sure Glucophage cannot replace the benefit of a Healthy lifestyle continue to follow any device about diet that you are doctor has given you and get some regular exercise.
Usual dose:
Children 10 years and over and adolescent usually start with 500 mg or 850 mg glucophage once a day.The maximum daily dose is 2000 mg Takken as 2 or 3 divided dose.Treatment of children between 10 and 12 year of age is only recommended on specific advice from your doctor as experience in this age group is limited adult usually start with 500 mg 850 mg glucophage two or three times a day or maximum daily dose of 3000 mg.Taken as 3 divided dose.If you take insulin to your doctor will tell you how to start glucophage.
How to take glucophage:
The glucophage with or after I meal.This will avoid you have side effect affecting your digestion.do not Crush or chew the tablet.Swallow each tablet with a glass of water.If you take one dose a day take it in the morning.If you take to divide those is a day take them in the morning and evening if you take three dose a day take them in the morning at noon and in the evening if after sometime you think that the effect of glucophage is too strong or too week talk to your doctor or pharmacist.
Monitoring:
Your doctor will perform regular blood glucose test and will adapt your dose of glucophage to your blood glucose level.make sure that you talk to your doctor regularly.This is particularly important for children and add adolescent or if you are an older person.Your doctor will also check at least once a year how will your kidney are not working normally.
Pregnancy and breast-feeding:
During pregnancy you need insulin to treat your diabetes tell your doctor if you are you think you might be or are planning to become pregnant.so that he or she may change your treatment this medicine is not recommended if you are breast feeding or if you are planning to breast feed your baby.
Driving and using machines:
Glucophage on its own doe not cause hypoglycemia this mean that it will not affect your ability to drive are you can machines.However take special case if you take glucophage together with other medicine to treat debate that can cause hypoglycemia importance of hypoglycemia include weakness increased sweating, vision disorder and difficulty in concentration.Do not drive or use machine if you start to feel this sympotoms.
Children and adolescent:
Limited data in children and adolescent showed that adevers event similarly in nature and severity to those reported in adults. if any of the side effect get serious or if you not if any side effect not listed in this leaflet.please tell yourdoctor or pharmacist.
Storage:
Store below 30 degree centigrade.
Protect from light heat and moisture.
Keep on medicine out of the reach of children
Manufacturer by:
Merck Private Limited
Nims Tablet - Uses, Side-effects, Reviews, Composition, Interactions
{{..NIMS..}}
Composition:
Each film coated tablet content Nimesulide.ph.Eur.....100mg
Pharmacodynamics:
Nimesulide is non steroidal anti- inflammatory drugs that selectively inhibits cyclooxygenase but it appears to exert it therapeutic effect through variety of other mechanism as well like inhibition of platelet activating factor tumor necrosis factor Alpha protease and histamine etc.
Pharmacokinetics:
Oral absorption of Nimesulide is almost complete.concomintant administration of food made decrease the rate but not the extent of absorption of Nimesulide. plasma binding is high (approximately 99%) .Nimsulide is extensively metabolized to several metabolites which are excreted mainly in the urine about 70% and in feces about 20%.
Usage:
Nimsulide being an NSAID. exhibit anti-inflammatory analgesic and anti-pyretic property it is indicated as second choice for the treatment or acute pain and primary dysmenorrhea.
Rarely nimsulide has been reported to be associated with seriouse hepatic reaction including very rare fatal case.patient who experrience sympotoms compatible with hepatic injury during treatment with laser light or patient who develop abnormal liver function tests should have treatment discontinued.this patient should not be Rechallenged with name of nimesulide liver damage in most cases reversible has been reported following short exposure to the drug.
Contra-Indication:
The use of Nimesulide is contraindicated and patient with hapatic impairment children active peptic ulcer disease is known hypersensitivity to the active substance acetic Acid or other prostaglandin synthetase inhibiting drugs.
Adverse Reactions:
At therapeutic dose is usually well tolerated.Occasional Side Effects include heartburn nausea and epigastric pain.skin rashes of allergic type may rarely occure.
Drugs interaction:
Clinically important interaction involving interference with drug metabolism have not been described with nimsulide.
Dosage And Administration:
usual oral dose is adults is one tablet twice daily for not more than 15 days.
OR
As directed by physical.
Stability:
See expiry on the pack
Presentation:
NIMS 100... MG Tablet in a pack of 20 tablet.
Instruction:
keep outkeep out of reach of children avoid exposure to heat light and human immunity power between 15 to 30 degree centigrade and improper storage may be deteriorate the medicine.
(100 MG TABLETS)
Nimesulide
Composition:
Each film coated tablet content Nimesulide.ph.Eur.....100mg
Pharmacodynamics:
Nimesulide is non steroidal anti- inflammatory drugs that selectively inhibits cyclooxygenase but it appears to exert it therapeutic effect through variety of other mechanism as well like inhibition of platelet activating factor tumor necrosis factor Alpha protease and histamine etc.
Pharmacokinetics:
Oral absorption of Nimesulide is almost complete.concomintant administration of food made decrease the rate but not the extent of absorption of Nimesulide. plasma binding is high (approximately 99%) .Nimsulide is extensively metabolized to several metabolites which are excreted mainly in the urine about 70% and in feces about 20%.
Usage:
Nimsulide being an NSAID. exhibit anti-inflammatory analgesic and anti-pyretic property it is indicated as second choice for the treatment or acute pain and primary dysmenorrhea.
Special warning and precaution for use
Hepatic Effects:Rarely nimsulide has been reported to be associated with seriouse hepatic reaction including very rare fatal case.patient who experrience sympotoms compatible with hepatic injury during treatment with laser light or patient who develop abnormal liver function tests should have treatment discontinued.this patient should not be Rechallenged with name of nimesulide liver damage in most cases reversible has been reported following short exposure to the drug.
Contra-Indication:
The use of Nimesulide is contraindicated and patient with hapatic impairment children active peptic ulcer disease is known hypersensitivity to the active substance acetic Acid or other prostaglandin synthetase inhibiting drugs.
Adverse Reactions:
At therapeutic dose is usually well tolerated.Occasional Side Effects include heartburn nausea and epigastric pain.skin rashes of allergic type may rarely occure.
Drugs interaction:
Clinically important interaction involving interference with drug metabolism have not been described with nimsulide.
Dosage And Administration:
usual oral dose is adults is one tablet twice daily for not more than 15 days.
OR
As directed by physical.
Stability:
See expiry on the pack
Presentation:
NIMS 100... MG Tablet in a pack of 20 tablet.
Instruction:
keep outkeep out of reach of children avoid exposure to heat light and human immunity power between 15 to 30 degree centigrade and improper storage may be deteriorate the medicine.
Manufactured by:
SAMI
Pharmaceuticals (PVT) LT
Sunday 30 July 2017
Cyrocin Tablet - Uses, Side-effects, Reviews, and Precautions
{{..CYROCIN..}}
{..CIPROLOXACIN HCL..}
(Film coated tablets)
COMPOSITION:
Cyrocin 250 MG Tablet is film coated tablet contents ciprofloxacin hydrochloride U.S.P…... 250 mg.
Cyrocin 500 MG Tablet is film coated tablet contents ciprofloxicin as hydrochloride U.S.P….. 500mg
Description:
Cyrocin is fluorinated 4- quinolone or antibacterial with a wider spectrum of activity then nalidixic acid and more favourable pharmacokinetics allowed it is used is systematic infection.
Mechanism Of Action:
Ciprofloxacin is a member of the fluoroquinolone class of antibacterial agent ciprofloxacin is a broad spectrum antibiotic that is active against both germ-positive and Gram-Negative bacteria the bacterial action of ciprofloxacin result from inhabitation of the enzymes topofisomerase ll and topoisomerase lV.which are required for bacterial DNA replication, transcription, repair and recombination.
Pharmacokinetics:
Ciprofloxacin is ready and well observed from the gastrointestinal tract oral.bioavailability is about 70 to 80% and peak plasma concentration of about 2.4 micrograms per Mol. occure 1 to 2 hour after 500 mg oral dose absorption of the ciprofloxacin may be delayed by the presence of food, but is not substantially affected overall.
The binding of ciprofloxacin to serum protein is 20% to 40% which is not likely to be high enough to cause significant protein binding interaction with Other Drugs.
Indications And Usage:
Cyrocin tablet is indicated for the treatment of infection caused by susceptible isolates of the designated micro-organisms in the condition and patient population listed below.
Urinary tract infection:
Cyrocin tablet is indicated in adult patients for treatment of urinary tract infection caused by Escherichia coli.
Acute uncomplicated cystitis:
Cyrocin tablet is indicated in Adult female patient for treatment of acute uncomplicated cystitis caused by Escherichia coli.
Chronic bacterial Prostatitis:
Cyrocin tablet is indicated in adverb patient for treatment of chronic bacterial Prostatitis caused by Escherichia coli.
Lower respiratory tract infections:
Cyrocin tablet is indicated in equal patient for treatment of lower respiratory tract infection caused by Escherichia coli cyrocin tablet is also indicated for the treatment of acute exacerbation of chronic brochititis cause by Moraxella catarrhails.
Acute sinusitis:
Cyrocin tablet is indicated in head rotation for treatment of acute Sinusitis caused by a haemophilus influenzae, streptococcus pneumoiaw.
Skin and skin structure infection:
Cyrocin tablet is indicated in adult patient for treatment of skin and skin structure infection caused by citrobactor freundii, methicillin susceptible.
Dosage and administration dosage in adults:
Determination of dosage and duration for any particular patient must take into consideration the severity and nature of the infection the susceptibility of the causative microorganism the integrity of the patient host defence mechanism and the status of renal and apathetic function.
Urine specific for population: pregnancy:
Pregnancy category C because no adequate or well control study has been conduct in pragnant women.cefrofloxacin should be used during pregnancy only if the patient benefit justify the potential risk to the fetus.
Nursing mother:
ciprofloxacin is excreted in the breast milk because of the potential risk of serious adverse reaction in the infants nursing from Mother taking cyrocin a decision should be made whether to discontinue nursing or to discontinue the drug taking into account the important of the drug to the moth
Paediatric uses:
Ciprofloxacin is not a drug of first choice in the pediatric population due to an increased incidence of adverse reaction compared to the control including event related to joint and / or surrounding tissues.
Fluoroqinolone Including ciprofloxacin have neuromuscular blocking activity and m.ay exacerbate muscle weakness in person with myasthenia gravis.ciprofloxacin in patient with
known history of myasthenia gravis.
Manufactured by:
Titlis Pharma
for
Highnoon Laboratories Ltd
{..CIPROLOXACIN HCL..}
(Film coated tablets)
COMPOSITION:
Cyrocin 250 MG Tablet is film coated tablet contents ciprofloxacin hydrochloride U.S.P…... 250 mg.
Cyrocin 500 MG Tablet is film coated tablet contents ciprofloxicin as hydrochloride U.S.P….. 500mg
Description:
Cyrocin is fluorinated 4- quinolone or antibacterial with a wider spectrum of activity then nalidixic acid and more favourable pharmacokinetics allowed it is used is systematic infection.
Mechanism Of Action:
Ciprofloxacin is a member of the fluoroquinolone class of antibacterial agent ciprofloxacin is a broad spectrum antibiotic that is active against both germ-positive and Gram-Negative bacteria the bacterial action of ciprofloxacin result from inhabitation of the enzymes topofisomerase ll and topoisomerase lV.which are required for bacterial DNA replication, transcription, repair and recombination.
Pharmacokinetics:
Ciprofloxacin is ready and well observed from the gastrointestinal tract oral.bioavailability is about 70 to 80% and peak plasma concentration of about 2.4 micrograms per Mol. occure 1 to 2 hour after 500 mg oral dose absorption of the ciprofloxacin may be delayed by the presence of food, but is not substantially affected overall.
The binding of ciprofloxacin to serum protein is 20% to 40% which is not likely to be high enough to cause significant protein binding interaction with Other Drugs.
Indications And Usage:
Cyrocin tablet is indicated for the treatment of infection caused by susceptible isolates of the designated micro-organisms in the condition and patient population listed below.
Urinary tract infection:
Cyrocin tablet is indicated in adult patients for treatment of urinary tract infection caused by Escherichia coli.
Acute uncomplicated cystitis:
Cyrocin tablet is indicated in Adult female patient for treatment of acute uncomplicated cystitis caused by Escherichia coli.
Chronic bacterial Prostatitis:
Cyrocin tablet is indicated in adverb patient for treatment of chronic bacterial Prostatitis caused by Escherichia coli.
Lower respiratory tract infections:
Cyrocin tablet is indicated in equal patient for treatment of lower respiratory tract infection caused by Escherichia coli cyrocin tablet is also indicated for the treatment of acute exacerbation of chronic brochititis cause by Moraxella catarrhails.
Acute sinusitis:
Cyrocin tablet is indicated in head rotation for treatment of acute Sinusitis caused by a haemophilus influenzae, streptococcus pneumoiaw.
Skin and skin structure infection:
Cyrocin tablet is indicated in adult patient for treatment of skin and skin structure infection caused by citrobactor freundii, methicillin susceptible.
Dosage and administration dosage in adults:
Determination of dosage and duration for any particular patient must take into consideration the severity and nature of the infection the susceptibility of the causative microorganism the integrity of the patient host defence mechanism and the status of renal and apathetic function.
Urine specific for population: pregnancy:
Pregnancy category C because no adequate or well control study has been conduct in pragnant women.cefrofloxacin should be used during pregnancy only if the patient benefit justify the potential risk to the fetus.
Nursing mother:
ciprofloxacin is excreted in the breast milk because of the potential risk of serious adverse reaction in the infants nursing from Mother taking cyrocin a decision should be made whether to discontinue nursing or to discontinue the drug taking into account the important of the drug to the moth
Paediatric uses:
Ciprofloxacin is not a drug of first choice in the pediatric population due to an increased incidence of adverse reaction compared to the control including event related to joint and / or surrounding tissues.
warnings and precautions
The following precaution and warning should be measured during cyrocin treatment are
Fluoroqinolone Including ciprofloxacin have neuromuscular blocking activity and m.ay exacerbate muscle weakness in person with myasthenia gravis.ciprofloxacin in patient with
known history of myasthenia gravis.
Manufactured by:
Titlis Pharma
for
Highnoon Laboratories Ltd
Pregnancy while taking progyluton | Trying to Conceive & Women's
{{..PROGYLUTON..}}
(ESTRADIOL VALERATE NORGESTRAL)
TABLETS
NAME OF THE MEDICINAL PRODUCT:
PROGYLUTON
QUALITATIVE AND QUANTITATIVE COMPOSITION:
Each white sugar-coated tablet contain estradiol valerate 2.0 mg
Each light brown sugar-coated tablet contain estradiol valerate 2.0 mg and nosrgestral 0.5 mg
CLINICAL PARTICULARS
INDICATION (S)
Hormone replacement therapy for the treatment of signs and symptoms of estrogen deficiency due to neutral menopause or hypogonadism Castration or primary ovarian failure in women with an intact uterus Prevention of postmenopausal osteoporosis.Control of irregular menstrual cycles treatment of primary or secondary amenorrhea.
DOSAGE REGIMEN
HOW TO START PROGYLUTON:
If the patient is in minus protein treatment should begin on the 5th day of the cycle first day of menstrual bleeding equal to first day of the cycle patient with amenorrhea or very infrequent period or who are postmenopausal may start at anytime provided pregnancy has been excluded.
DOSAGE:
1 white tablet is taken daily for the first 11 days followed by 1 light brown tablet daily for 10 days.
Following the 21 days of tablet taking there will be a tablet free interval of 7 days
ADMINISTRATION:
Each pack covers 21 days of treatment.A new pack of progyluton should be started after the seven days Tablet free interval on the same day of the week as the previous one.The tablets are be swallowed whole with some liquid the tablet should preferably be taken at the same time everyday.
MISSED TABLETS:
In case a tablet is forgotten, it should be taken as soon as possible if more than 24 hours have elapsed no extra tablet need to be taken if several tablet are forgotten bleeding may occur bleeding usually occur during the tablet free interval of 7 days within a few days after the last tablet was taken
{{..ADDITIONAL INFORMATION ON A SPECIAL POPULATIONS..}}
CHILDREN AND ADOLESCENTS
Progyluton is not indicated for use in children and adolescents
GERIATRIC PATIENTS:
There are no data suggesting a need for dosage adjustment in elderly patients in women aged 65 years or older see-section special warnings and precautions for use
PATIENT WITH RENAL IMPAIRMENT:
Progyluton has not been specifically studied in patient with hepatic impairment. Progyluton is contraindicated in women with severe hepatic diseases.
PATIENT WITH RENAL IMPAIRMENT:
Progyluton have not been specifically studied in renally impaired patients available data do not suggest a need for Dosage adjustment in this patient population.
SPECIAL WARNING AND PRECAUTION FOR USE:
Before initiating therapy all conditions/risk factor mentioned below should be considered when determining the individual benefit/ risk of treatment for the patient during HRT use therapy should be discontinued immediately in case a contraindication is discovered heavy rain in the following situation.Migrainous frequent and unusually severe headache is that accur for the first time or other symptoms that are possible for prodroma of cerebrovascular occlusion.Recurrence of cholestatic jaundice or cholestatics pruprite which occurred first during pregnancy or previous of sex steroid.
PREGNANCY AND LACTATION:
HRT is not indicated for use during pregnancy or lactation.if pregnancy occur during medication with progyluton treatment should be discontinued immediately small amount of sex hormones may be excreted in human milk.
.
CHILDREN AND ADOLESCENTS
Progyluton is not indicated for use in children and adolescents.
GERIATRIC PATIENTS:
There are no data suggesting a need for dosage adjustment in elderly patients in women aged 65 years or older see-section special warnings and precautions for use.
PATEINT WITH HEPATIC IMPAIRMENT:
Progyluton has not been specifically studied in patient with hepatic impairment. Progyluton is contraindicated in women with severe hepatic diseases.
PATIENT WITH RENAL IMPAIRMENT:
Progyluton have not been specifically studied in renally impaired patients available data do not suggest a need for Dosage adjustment in this patient population.
SPECIAL WARNING AND PRECAUTION FOR USE
Before initiating therapy all conditions/risk factor mentioned below should be considered when determining the individual benefit/ risk of treatment for the patient during HRT use therapy should be discontinued immediately in case a contraindication is discovered heavy rain in the following situation.Migrainous frequent and unusually severe headache is that accur for the first time or other symptoms that are possible for prodroma of cerebrovascular occlusion.Recurrence of cholestatic jaundice or cholestatics pruprite which occurred first during pregnancy or previous of sex steroid.
PREGNANCY AND LACTATION
HRT is not indicated for use during pregnancy or lactation.if pregnancy occur during medication with progyluton treatment should be discontinued immediately small amount of sex hormones may be excreted in human milk.
PHARMACOLOGICAL PROPERTIES
PRECLINICAL SAFETY DATA:
The result from toxicity with repeated administration including tumorigenicity studies with the two active substances are not suggest of a particular risk related to use in human however, it has to be Born in mind that sex sreriod can promote the growth of certain hormone dependent tissues and tumor.
.
MANUFACTURED BY:
BAYER WEIMAR GMBH AND CO.KG, WEIMAR GERMANY
Anti-Allergy Medication Tablet Uses
{{ ..XADINE..}}
(FEXOFENADINE HCL USP)
TABLETS
DESCRIPTION:
FEXIFENADINE HYDROCHLORIDE:
USP the active ingredient of xadine is histamine H1.Receptor antagonist with the chemical name.
The molecular weight is 538.13 and empirical formula is C32, H39 N04 HCL.
COMPOSITION:
XADINE 60 MG TABLETS:
Each film coated tablet contain 60mg fexofenadine hydrochloride USP as actve ingredient.
120mg fexofenadine hydrochloride USP as actve ingredient.
180mg fexofenadine hydrochloride USP as actve ingredient.
CLINICAL PHARMACOLOGY:
MECHANISM OF ACTION:
Fexofenadine a metabolite of terfenadine is an antiìstanine with selective peripheral H1. Recepotor antagoist activity. Fexofenadine antigen-induced bronchospasm and histamine release from peritoneal mast cells. No anticho5inergic or alpha 1.
Adregenic receptor blocking effects was abserved. Moreover, no sedative or other central nervous system efects were abserved. Fexofenatine does not cross the blood-brain barrier
PHARMACOKINETICS:
Fexofenadine hydrochloride was rapdily absorbed with a mean time to maximum plasma concentration occuring at 2.6 hours post dose. Althrough the absolute bioavailability of fexofenadine hydrochloride tablet is unknown. Thetablet is bioequitalent to an oral solution. The mean elimination half-life of fexofenadine was 14.4 hours of 60 mg twice daily.
SPECIAL POPULATION:
Special population pharmacokinetics obtaine after a single doso of 80 mg. These special population patients were subtantielly older. Thus an age effect may be confounding the pharmacokinetic differences observed in some of the special populations.
EFFECT OF AGE:
In older subjects (> 65 years old) peak plasma levels of bexofenadine were 99 % greater than thore (< 65 years old) mean elimination half-lives were simillar to those observed in normal.
HEPATICALLY IMPAIRED:
Across reveral trials,no clinicaly significant gender-realated differences where observerd in the pharmacokinetics of fexofenadiine.
PHARMACODYNAMICS:
WHEAL AND FLARE:
Human histamine skine weal and flare studies following single and twice daily doses of 20 mg and 40 mg fexofenadine demostrated that the drug exhibits an antihistamine effect by 1 hour, achieves maximum effect at 2-3 hours and an effect is still seen at 12 hourse. There was no evidence of tolerance to these effects after 28 days of dosing.
INDICATIONS:
XADINE 60 MG AND XADINE 120 MG.:
Xadin 60 mg tablet/xadine 120 mg tablet is indicated for the relief of symptoms associated with seasonal allergic rhinitis in adualts and children 12 year of age and older. Symptoms treated effectively include sneezing, rhinorrhea, itchy nose /palate / throat /itchy /watery /red eyes.
XADINE 180 MG TABLETS:
Xadine 180 mg tablets is indicated for the relief of symptoms associated with chronic idiopathic urticaria.
PREGNANCY:
TERATOGENIC EFFECTS:
Category c. There are no adeguate and well controlled studies in pregnant women. Fexofenadine should be used during pregnancy only it the potential benefit justifies the poptential risk to the fetus
INSTRUCTIONS:
TO BE SOLD ON PRESCRIPTION OF A REGISTERED MEDICAL PRACTITIONER ONLY.
PROTECT FROM MOISTURE,FREEZING, EXCESSIVE HEAT AND SUNLIGHT
.
(FEXOFENADINE HCL USP)
TABLETS
DESCRIPTION:
FEXIFENADINE HYDROCHLORIDE:
USP the active ingredient of xadine is histamine H1.Receptor antagonist with the chemical name.
The molecular weight is 538.13 and empirical formula is C32, H39 N04 HCL.
COMPOSITION:
XADINE 60 MG TABLETS:
Each film coated tablet contain 60mg fexofenadine hydrochloride USP as actve ingredient.
120mg fexofenadine hydrochloride USP as actve ingredient.
180mg fexofenadine hydrochloride USP as actve ingredient.
CLINICAL PHARMACOLOGY:
MECHANISM OF ACTION:
Fexofenadine a metabolite of terfenadine is an antiìstanine with selective peripheral H1. Recepotor antagoist activity. Fexofenadine antigen-induced bronchospasm and histamine release from peritoneal mast cells. No anticho5inergic or alpha 1.
Adregenic receptor blocking effects was abserved. Moreover, no sedative or other central nervous system efects were abserved. Fexofenatine does not cross the blood-brain barrier
PHARMACOKINETICS:
Fexofenadine hydrochloride was rapdily absorbed with a mean time to maximum plasma concentration occuring at 2.6 hours post dose. Althrough the absolute bioavailability of fexofenadine hydrochloride tablet is unknown. Thetablet is bioequitalent to an oral solution. The mean elimination half-life of fexofenadine was 14.4 hours of 60 mg twice daily.
SPECIAL POPULATION:
Special population pharmacokinetics obtaine after a single doso of 80 mg. These special population patients were subtantielly older. Thus an age effect may be confounding the pharmacokinetic differences observed in some of the special populations.
EFFECT OF AGE:
In older subjects (> 65 years old) peak plasma levels of bexofenadine were 99 % greater than thore (< 65 years old) mean elimination half-lives were simillar to those observed in normal.
HEPATICALLY IMPAIRED:
Across reveral trials,no clinicaly significant gender-realated differences where observerd in the pharmacokinetics of fexofenadiine.
PHARMACODYNAMICS:
WHEAL AND FLARE:
Human histamine skine weal and flare studies following single and twice daily doses of 20 mg and 40 mg fexofenadine demostrated that the drug exhibits an antihistamine effect by 1 hour, achieves maximum effect at 2-3 hours and an effect is still seen at 12 hourse. There was no evidence of tolerance to these effects after 28 days of dosing.
INDICATIONS:
XADINE 60 MG AND XADINE 120 MG.:
Xadin 60 mg tablet/xadine 120 mg tablet is indicated for the relief of symptoms associated with seasonal allergic rhinitis in adualts and children 12 year of age and older. Symptoms treated effectively include sneezing, rhinorrhea, itchy nose /palate / throat /itchy /watery /red eyes.
XADINE 180 MG TABLETS:
Xadine 180 mg tablets is indicated for the relief of symptoms associated with chronic idiopathic urticaria.
PREGNANCY:
TERATOGENIC EFFECTS:
Category c. There are no adeguate and well controlled studies in pregnant women. Fexofenadine should be used during pregnancy only it the potential benefit justifies the poptential risk to the fetus
INSTRUCTIONS:
TO BE SOLD ON PRESCRIPTION OF A REGISTERED MEDICAL PRACTITIONER ONLY.
PROTECT FROM MOISTURE,FREEZING, EXCESSIVE HEAT AND SUNLIGHT
.
{{-- KEEP OUT OF THE REACH OF CHILDREN--}}
MFG:
USP Spec
MANUFACTURED BY :
THE SEARLE COMPANY
LIMITED
Saturday 29 July 2017
PURPAL (ESOMAPRAZOLE ) ///// CAPSULES USES
{{..PURPAL..}}
[ESOMEPRAZOLE MAGNESIUM]
[CAPSULE]
COMPOSITION: Purpal 40 mg: Each capsule equaivalent to Esomeprazole 40 mg
purple 20 mg: Each capsule equaivalent to Esomeprazole 20 mg
PHARMACOLOGICAL CLASSIFICATION: Proton pump inhibitor
DESCRIPTION:
The active ingredients in puple /DELAYED RELEASE CAPSULE/ is bis [(S)-[(4-methoxy-3, 5-dimethyle-2-pyridinyl)
1 CLINICAL PHARMACOLOGY:
ABSORPTION:
purple delayed release capsules contain in enteric-coated pellet formulation of esomeprazole.so that absorption of esomaprazole begins only after the granules leave the stomach.After oral administration, peak plasma levels occure at approximately 1.5 houres.The increase proportionally when the dose is increased and there is a three fold increase in the area under the plasma concentration time corve from 20 40 mg.
DISTRIBUTION PURPAL:
Distribution purpal is 97% bound to plasma protiens.Plasma orotien binding over the concentration range 2 to 20 mol/L.The apparent volum of distribution at steady state in healthy volunteers is approximatly 16L.
EXCRETION:
The plasma elimination half-life of purpal is approximatlly 1.5 hours.Less then 1 % of parent drugs is excreted in the urine. Approximatelly 80 % of an oral dose of pupale is excreted is inactive metabolites in the urine and the remainder is found as inactive metabolites
in the faces,
.
2 PHARMACODYNAMICS:
MECHANISM OF ACTION:
Esomeprazole is a proton pump inhibitor that suppress gastric acid secretion by specific inhibition of the H/K-ATPASE in the gastric parietal cell. The S and R isomers of omeprazole are protonated and converted in the acidic compartment of the parietal cell forming the active inhibitor the achiral sulphenamide. By acting specifically on the proton punp.Eromeprazole blocks the final step in acidic production thus reducing gastric acidity.
3 INDICATIONS AND USAGE
HEALING OF EROSIVE ESOPHAGITIS: Purpal is indicated for the short-time treatment (4 to 8 weeks) in healing and symptomatic resolution of diagnostically confirmed erosive esophagitis. For those patients who have not healed after 4 to 8 weeks of treatment, an additional 4 to 8 weeks course of purpal may be considered
.
HEARTBURN AND OTHER SYMPTOMS:
Pupal delayed release capsules are indicated for the treatment of heartburn and other symptoms associated with GERD
.
MAINTENANCE OF HEALING OF EROSIVE ESOPHAGITIS:
Purpal delayed release capsules are indicated to maintain symptoms resolution andhealing of erosive esophagitis. Controlled studies do no extend beyond 6 months
.
CONTRAINDICATIONS:
Purpal capsules are contraindicated in patients with know hypersensitivity to any component of the formulation.
WARNINGS:
CLARITHROMYCIN: it should not be use in pregnant women except in clinical circumstances where no alternative therapy is appropriate If pregnancy occurs while taking clarithromycin. The patient should be apprised of the potential hazard to the fetus..
AMOXICILLIN:
Serious and occasionally fatal hypersensitivity reactions have been reported in patients on penicillin therapy. These reactions are more likely to occur in individuals with a history of penicillin hypersensitivity and/or a history of sensitivity to multiple allergens.
MANUFACTURED BY:
DYSON RESEARCH
LABORATORIES (PVT.)LTD
ISO 9001:2000 CERTIFIED
COMPANY
