SOFVASC TABLETS Amlodipine (Besylate):5mg

                                                                      Sofvasc

                                                                      Tablets 

Composition:
Each tablet contain:
Amlodipine besylate eq. to amlidopine BP/Eur. P …...5 & 10 mg

Description:
Amlodipine is a Calcium Ion influx inhibitor and the transmembrane influx of calcium ion into cardiac and smooth muscles.the antihypertensive action is due to direct relaxant and effect on vascular smooth muscle the exact mechanism of action with regard to angina has not been fully determined but amlidopine reduce total ischemic burden by the following to actions.

1= Amlidopine dilates peripheral thus  reduce the total peripheral resistance against with the heart work.since there is no associated reflex tachycardia this unloading of the heart reduce myocardial energy consumption and oxygen requirement and probably account for the effectiveness of amlidopine in myocardial ischemia.

2= The mechanism of action of amlodipine probably involved dilation of the main coronary arteries and coronary arterioles but a normal and ischemic region. this dilqtion increase myocardial oxygen delivery in patient with coronary artery spasm.

Pharmacology:
After oral administration of therapeutic dose.amlidopine is not defined as well obsorbed.The terminal plasma elimination Half-Life is about 35-65 hour and consistent with once daily dosing. steady state plasma level are achieved after 7-8 days of constructive dosing and define is extensively metabolized by the liver to inactive metabolies with 10% of parent compound and 60% of metabolies excreted in urine. In patient with hypertension once daily dosing provids clinically significant reduction of blood pressure in both supine and standing position throughout the 24 hour interval.

                                                             Indicationns

hypertension:
Sofvasc tablet are indicated for the first line treatment of hypertension and can control blood pressure as a sole agent in majority of patients all through the thiazide diuretic, Beta blocker of an inhibitor may be given in addition if required.

Myocardial ischemia:
Sofvasc tablet are indicated for the first line treatment of myocardial ischemia either alone or in combination with Other anti-anginal Drugs.

Contra-indication:
Amlodipine is contraindicated in patient with known hypersensitivity to dihydropyridiness.

Possible adverb effect:
Amlidopine is generally well tolerated while most commonly observed side effect were headache, edema,  fatigue,  nausea flushing and dizziness.


Drug interactions:
Amlidopine has been safely administrated with thaizide  diuretic Beta blocker angiotensin converting enzyme inhibitors long active nitrate sublingual nitroglycerine non steroidal anti inflammatory drug.inhibtors and oral hypoglycemic drugs.

                                                                    Warnings:

Use in pregnancy and lactation: Safety of the drug has not been established in pregnancy and lactation:
Used in elderly:
Normal dosage the mines are recommended in into the patient. Use in renal faliur:
Amlodipine is extensively metabolised to inactive metabolities with 100% excreted as unchanged in the urine. therefore and define may be used in such patient at normal dose.

                                                        Used in hepatic impairment

impairment:
 Half life of drug is prolonged in patient with hepatic impairment and dosage recommendation in such patient have not been established the drugs should therefore be administered with caution in such patients.

Storage/precautions:
store in a cool dry and dark place between 15-30 degree centigrade keep all medicine out of the children's reach.

Presentation:
Sofvasc 5 and 10 mg tablet are available in packing containing 30 tablet Wilsonspecs.
complete medical information available only for doctor on request.

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Tenormin: Uses, Dosage & Side Effects - Drugs.com

                                                                  {.. Tenormin..}

                                                                     (Atenolol)

Composition:
Each film coated tablet content 25 mg,50 mg,100 mg of atenolol.
 Injection for intravenous use presented as an isotonic citrate buffered,aqueous solution containing 5 mg of atenolol ph.Eur.in 10 ml.

Therapeutic Indications:
 Hypertension
Angina pectoris
cardiac arrhythmias

Posology And Method Of Administration:
The dose must always be adjusted  to individual requirement of the patient with the lowest possible starting dosage.
 the following are guidelines.

                                                              Adult:

Hypertension:
One tablet daily most patient respond 200 mg daily given orally as a single dose some patient however will respond to 50 mg given as a single daily dose the effect will be fully established after 1 or 2 week a further reduction in blood pressure may be achieved by combining tenormin with other antihypertensive agents for example co administration of tenorman with a diuretic provides a Highly Effective and convenient antihypertensive therapy.

Angina:
Most patient with angina pectoris will respond 200 mg given orally once or 50 mg given twice daily it is unlikely that additional benefit will be gained by increasing the dose.

Cardiac Arrhythmia’s:
A suitable initial dose of tenormin is 2.5 mg injected intravenously over 2.5 minute period this may be repeated at 5 minute interval until a response is observed up to a maximum dosage of 10 mg tenormin is given by infusion 0.15 MG per KG body weight may be administered over a 20 minute period if required the Injection or infusion may be repeated every 12 hour.Having controlled the arrhythmias with intravenous tenormin a suitable oral maintenance dose ages 50 to 100 MG daily given as a single dose.

Elderly:
 Does requirement may be reduced especially in patient with impaired renal function.

Children:
There is no paediatric experience with tenormin and for this reason it is not recommended for use in children.

Renal Failure:
 since the tenormin excreted via then kidney the door that should be reduced in case of severe impairment of renal function no significant accumulation of tenement occur in patients who have a creatinine clearance greater than 35 ml per minute per 1.73 metre square.

Contraindications:
Tenorman as with other Beta blocker should not be used in patient with any of the following:
 Hypersensitivity to the active substance, or any of the excipient bradycardia cardiogenic shock. hypertension metabolic acidosis;Severe peripheral articles circulatory disturbance second or third degree heart block sick sinus syndrome;Untreated  phaeochromocytoma;
Uncontrolled heart failure.

                                  Special warnings and precaution for use

tenormin as with other Beta blocker:
should not be with drawn abruptly. should be withdrawn gradually over a period of 7-14 days to facilitate.
A reduction in the beta blocker dosage.Patient should be followed during withdrawal especially those with ischaemic heart diseases.

Pregnancy and lactation:
The tenormin cross the placental barrier and appeared in the cord blood no studies have been performed on the use of tenormin in the first trimester and the possibility of foetal injury cannot be excluded.Tenormin has been used under close supervision for the treatment of hypertension in the third trimester. Administration of the tenormin to pregnant women in the management of mild to moderate hypertension has been associated with intra uterine growth retardation:

Effect on ability to drive and used machines:
Used as  unlikely to result in any impairment of the ability of patient to drive or operate machinery however it should be taken into account that occasionally dizziness or fatigue may occur.

Undesirable effect:
Tenormin is well tolerated.In clinical studies the undesired events trip reported are usually attributable to the pharmacological action of atenolol.
Following undesired events listed by body system has been reported with the following frequencies very common >10% common 1-9.9% uncommon 0.1-0.9%.

Overdose:
The symptoms of overdosage May include bradycardia hypotension acute cardiac insufficiency and bronchaspasm.


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Glucophage Oral : Uses, Side Effects, Interactions, Pictures, Warnings

                                                 {..GLUCOPHAGE..}

                                    (METFORMIN HYDROCLORIDE)

                                                        TABLETS

                                                (MERCK SERONO)

Composition:
Glucophage tablet 250 mg:
Each film coated tablet contain metformin hydrochloride ph. Eur……….250 mg

Glucophage tablet 500 mg:
Each film coated tablet contain metformin hydrochloride ph. Eur……….500 mg

Glucophage tablet 850 mg:
Each film coated tablet contain metformin hydrochloride ph. Eur……….850 mg

Glucophage tablet 1000 mg:
Each film coated tablet contain metformin hydrochloride ph. Eur……….100 mg

Read all of this leaflet carefully before you start taking this medicine because it contain important information for you: 

keep this leaflet,you may need to read it again.
if you have further questions, ask your doctor or your Pharmacist.
 This medicine has been prescribed for you only.
 Do not pass it into other It may harm them even if their sign of illness are the same as your.
 If you get any side effect talk to your doctor or pharmacist.
 This includes any possible Side Effects not listed in this leave it what is in this leaflet.
what is glucophage tablet?
what are the indication for glucophage tablet ?
what should be the dose of glucophage Tablet?
 what are the contraindication of  glucophage best tablet?
 what are the adverse effect of  glucophage tablet?

what is glucophage tablet?
Glucophage is a medicine to treat diabetes.it belongs to a group of medicine called biguanides. insulin is a hormone produced by the pancreas that makes your body take in glucose from the blood your body uses glucose to produce energy stores.
 It for future use
 If you have diabete your pancreas does not make in insulin or your body is not able to use properly the insulin it produce this lead to a high level of glucose in your blood glucose help to lower your blood glucose to as normal as level as possible.If you are an overweight, adult,taking glucophage over a long period of time also help to lower the risk of complications associated with daibetes.

What are the indication for glucophage tablet:
Glucophage is used to treat patient with type 2 diabetes with diet and exercise alone have not been enough to control your blood glucose levels.
 It is used particularly in overweight patient adult can take Glucophage on its own or together with other medicine to treat diabetes children 10 years and over and adolescent can take glucophage
on its on or together with incident it is also indicated for the prevention of type 2 Diabetes mellitus in patients with pre-diabetes and at least one additional risk factor in whom Lifestyle modification alone have not reach adequate glycaemic  control.

What should be the dose of glucophage tablet?
Always take Glucophage exactly as your doctor has told you check with your doctor or pharmacist. if you are not sure Glucophage cannot replace the benefit of a Healthy lifestyle continue to follow any device about diet that you are doctor has given you and get some regular exercise.

Usual dose:

Children 10 years and over and adolescent usually start with 500 mg or 850 mg glucophage once a day.The maximum daily dose is 2000 mg Takken as 2 or 3 divided dose.Treatment of children between 10 and 12 year of age is only recommended on specific advice from your doctor as experience in this age group is limited adult usually start with 500 mg 850 mg glucophage two or three times a day or maximum daily dose of 3000 mg.Taken as 3 divided dose.If you take insulin to your doctor will tell you how to start glucophage.

How to take glucophage:
The glucophage with or after I meal.This will avoid you have side effect affecting your digestion.do not Crush or chew the tablet.Swallow each tablet with a glass of water.If you take one dose a day take it in the morning.If you take to divide those is a day take them in the morning and evening if you take three dose a day take them in the morning at noon and in the evening if after sometime you think that the effect of glucophage is too strong or too week talk to your doctor or pharmacist.
Monitoring:
Your doctor will perform regular blood glucose test and will adapt your dose of glucophage to your blood glucose level.make sure that you talk to your doctor regularly.This is particularly important for children and add adolescent or if you are an older person.Your doctor will also check at least once a year how will your kidney are not working normally.

Pregnancy and breast-feeding:
 During pregnancy you need insulin to treat your diabetes tell your doctor if you are you think you might be or are planning to become pregnant.so that he or she may change your treatment this medicine is not recommended if you are breast feeding or if you are planning to breast feed your baby.

Driving and using machines:
 Glucophage on its own doe not cause hypoglycemia this mean that it will not affect your ability to drive are you can machines.However take special case if you take glucophage together with other medicine to treat debate that can cause hypoglycemia importance of hypoglycemia include weakness increased sweating, vision disorder and difficulty in concentration.Do not drive or use machine if you start to feel this sympotoms.

Children and adolescent:
Limited data in children and adolescent showed that adevers event similarly in nature and severity to those reported in adults. if any of the side effect get serious or if you not if any side effect not listed in this leaflet.please tell yourdoctor or pharmacist.

Storage:
Store below 30 degree centigrade.
 Protect from light heat and moisture.

                                              Keep on medicine out of the reach of children 
                                                                                                                                 Manufacturer by:

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Nims Tablet - Uses, Side-effects, Reviews, Composition, Interactions

                                                                        {{..NIMS..}}
                                                               

                                                                  (100 MG TABLETS)

                                                                           Nimesulide

 Composition:
 Each film coated tablet content Nimesulide.ph.Eur.....100mg

  Pharmacodynamics:
 Nimesulide is non steroidal anti- inflammatory drugs that selectively inhibits cyclooxygenase but it appears to exert it therapeutic effect through variety of other mechanism as well like inhibition of platelet activating factor tumor necrosis factor Alpha protease and histamine etc.

Pharmacokinetics:
Oral absorption of Nimesulide is almost complete.concomintant administration of food made decrease the rate but not the extent of absorption of Nimesulide. plasma binding is high (approximately 99%) .Nimsulide is extensively metabolized to several  metabolites which are excreted mainly in the urine about 70% and in feces about 20%.

Usage:
Nimsulide being an NSAID.  exhibit anti-inflammatory analgesic and anti-pyretic property it is indicated as second choice for the treatment or acute pain and primary dysmenorrhea.

                                       Special warning and precaution for use

Hepatic Effects:
Rarely nimsulide has been  reported to be  associated with seriouse hepatic reaction including very rare fatal case.patient who experrience sympotoms compatible with hepatic injury during treatment with laser light or patient who develop abnormal liver function tests should have treatment discontinued.this patient should not be Rechallenged with name of nimesulide liver damage in most cases reversible has been reported following short exposure to the drug.

Contra-Indication:
 The use of Nimesulide is contraindicated and patient with hapatic impairment children active peptic ulcer disease is known hypersensitivity to the active substance acetic Acid or other prostaglandin synthetase inhibiting drugs.

Adverse  Reactions:
At therapeutic dose  is usually well tolerated.Occasional Side Effects include heartburn nausea and epigastric pain.skin rashes of allergic type may rarely occure.

Drugs interaction:
Clinically important interaction involving interference with drug metabolism have not been described with nimsulide.

                                                Dosage And Administration:

usual oral dose is adults is one tablet twice daily for not more than 15 days.

OR

As directed by physical.

Stability:
See expiry on the pack

Presentation:
NIMS 100... MG Tablet in a pack of 20 tablet.

Instruction:
keep outkeep out of reach of children avoid exposure to heat light and human immunity power between 15 to 30 degree centigrade and improper storage may be deteriorate the medicine.

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                                                                                                        Pharmaceuticals (PVT) LT

                                                                                                  

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